The following is a list of notable earthquakes which had their epicenter in areas that are now part of the United States.
| Date | State | Magnitude | Fatalities | Further information |
|---|---|---|---|---|
| January 26, 1700 | 8.7 - 9.2 | 1700 Cascadia earthquake | ||
| November 18, 1755 | Massachusetts(then Massachusetts Bay Colony | 5.9 | 1755 Cape Ann earthquake | |
| December 16, 1811 | Missouri | 7.2 - 8.1 | 1811-1812 New Madrid earthquakes | |
| January 9, 1857 | California | 7.9 | 2 | 1857 Fort Tejon earthquake |
| April 24, 1867 | Kansas | 5.1 | 1867 Manhattan earthquake | |
| April 2, 1868 | Hawaii | 7.9 | 77 | 1868 Hawaii earthquake |
| October 21, 1868 | California | 6.8 - 7.0 | 30 | 1868 Hayward earthquake |
| December 14, 1872 | Washington | 6.5 - 7.0 | 1872 North Cascades earthquake | |
| March 26, 1872 | California | 7.6 - 8.0+ | 27 | 1872 Lone Pine earthquake |
| August 31, 1886 | South Carolina | 7.3 | 60-110 | 1886 Charleston earthquake |
| April 18, 1906 | California | 7.9 | 3000+ | 1906 San Francisco earthquake |
| September 27, 1909 | Indiana | 5.1 | 1909 Wabash River earthquake | |
| October 3, 1915 | Nevada | 7.1 | 1915 Pleasant Valley earthquake | |
| August 16, 1931 | Texas | 5.8 | 0 | 1931 Valentine earthquake |
| March 10, 1933 | California | 6.4 | 120 | 1933 Long Beach earthquake |
| December 20, 1940 | New Hampshire | 5.5 | 1940 New Hampshire earthquake | |
| April 1, 1946 | Alaska | 7.8 | 165 | 1946 Aleutian Islands earthquake |
| May 6, 1947 | Wisconsin | Unknown | 0 | 1947 Wisconsin earthquake |
| December 4, 1948 | California | 6.0 - 6.5 | 0 | 1948 Desert Hot Springs earthquake |
| April 13, 1949 | Washington | 7.1 | 8 | 1949 Olympia earthquake |
| July 21, 1952 | California | 7.5 | 14 | 1952 Kern County earthquake |
| March 9, 1957 | Alaska | 8.6 | 0 | 1957 Andreanof Islands earthquake |
| July 9, 1958 | Alaska | 8.3 | 5 | 1958 Lituya Bay earthquakes |
| August 17, 1959 | Montana, Wyoming | 7.3 - 7.5 | 28+ | 1959 Yellowstone earthquake |
| March 27, 1964 | Alaska | 9.2 | 143 | 1964 Alaska earthquake |
| February 4, 1965 | Alaska | 8.7 | 0 | 1965 Rat Islands earthquake |
| April 29, 1965 | Washington | 6.5 | 3 | 1965 Olympia earthquake |
| November 9, 1968 | Illinois | 5.4 | 0 | 1968 Illinois earthquake |
| October 2, 1969 | California | 5.6 - 5.7 | 1 | 1969 Santa Rosa earthquakes |
| February 9, 1971 | California | 6.6 | 65 | 1971 San Fernando earthquake |
| July 9, 1975 | Minnesota | 4.6 | 0 | 1975 Morris earthquake |
| May 2, 1983 | California | 6.5 | 0 | 1983 Coalinga earthquake |
| October 28, 1983 | Idaho | 7.3 | 2 | 1983 Borah Peak earthquake |
| April 24, 1984 | California | 6.2 | 0 | 1984 Morgan Hill earthquake |
| October 1, 1987 | California | 5.9 | 8 | 1987 Whittier Narrows earthquake |
| October 17, 1989 | California | 6.9 | 63 | 1989 Loma Prieta earthquake |
| April 25–26, 1992 | California | 6.5 - 7.2 | 0 | 1992 Cape Mendocino earthquakes |
| June 28, 1992 | California | 7.3 | 3 | 1992 Landers earthquake |
| June 28, 1992 | California | 6.5 | 0 | 1992 Big Bear earthquake |
| March 25, 1993 | Oregon | 5.6 | 0 | 1993 Scotts Mills earthquake |
| January 17, 1994 | California | 6.7 | 33 | 1994 Northridge earthquake |
| April 14, 1995 | Texas | 5.7 | 0 | 1995 Marathon earthquake |
| May 2, 1996 | Washington | 5.6 | 0 | 1996 Duvall earthquake |
| September 25, 1998 | Pennsylvania | 5.2 | 0 | 1998 Pymatuning earthquake |
| October 16, 1999 | California | 7.1 | 0 | 1999 Hector Mine earthquake |
| February 28, 2001 | Washington | 6.8 | 1 | 2001 Nisqually earthquake |
| November 3, 2002 | Alaska | 7.9 | 0 | 2002 Denali earthquake |
| April 29, 2003 | Alabama | 4.6 | 0 | 2003 Alabama earthquake |
| December 9, 2003 | Virginia | 4.5 | 0 | 2003 Virginia earthquake |
| December 22, 2003 | California | 6.5 | 2 | 2003 San Simeon earthquake |
| September 10, 2006 | Florida | 5.8 | 0 | 2006 Gulf of Mexico earthquake |
| October 15, 2006 | Hawaii | 6.7 | 0 | 2006 Hawaii earthquake |
| October 30, 2007 | California | 5.6 | 0 | 2007 Alum Rock earthquake |
| December 19, 2007 | Alaska | 7.2 | 0 | 2007 Andreanof Islands earthquake |
| April 18, 2008 | Illinois | 5.4 | 0 | 2008 Illinois earthquake |
| July 29, 2008 | California | 5.5 | 0 | 2008 Chino Hills earthquake |
| January 9, 2010 | California | 6.5 | 0 | 2010 Eureka earthquake |
| February 10, 2010 | Illinois | 3.8 | 0 | 2010 Illinois earthquake |
| July 7, 2010 | California | 5.4 | 0 | 2010 Borrego Springs earthquake |
| December 30, 2010 | Indiana | 3.8 | 0 | 2010 Indiana earthquake |
| August 22, 2011 | Colorado | 5.3 | 0 | 2011 Colorado earthquake |
| August 23, 2011 | Virginia | 5.8 | 0 | 2011 Virginia earthquake |
| September 2, 2011 | Alaska | 6.8 | 0 | 2011 Alaska earthquake |
| November 5, 2011 | Oklahoma | 5.6 | 0 | 2011 Oklahoma earthquake |